Ratio-Clarithromycin® tablets

Manufacturer:
Ratiopharm Inc.

Generic Name:
clarithromycin

Product Illustration Form:
tablet

Route:
oral


Why is it prescribed?

Ratio-Clarithromycin® tablets contains clarithromycin.

Clarithromycin is used to treat infections caused by susceptible bacteria. This material will be limited to infections of the respiratory tract (e.g. pneumonia, tonsilitis, sinuses, sore throat) and the middle ear.

 

Side Effects

Ratio-Clarithromycin® tablets contains clarithromycin.

Along with its needed effects, clarithromycin may cause some unwanted or undesirable effects. Generally, clarithromycin is well tolerated and many people will not experience unwanted effects. The frequency and severity of these effects is dependant on many factors including dose, duration of therapy and individual susceptibility. Possible unwanted effects include:

  • diarrhea
  • nausea
  • abnormal taste
  • stomach discomfort
  • indigestion
Uncommon:
  • allergy (e.g. hives, itching, rash, difficulty breathing)
  • headache
  • dizziness
  • constipation
  • diaper rash
  • oral candidiasis (thrush)
  • vomiting
Rare:
  • jaundice (yellowing of skin or eyes)
  • difficulty breathing
  • confusion
  • hallucinations
  • nightmares

 

Precautions and Warnings for Ratio-Clarithromycin® tablets

Ratio-Clarithromycin® tablets contains clarithromycin

Allergic reactions can occur with clarithromycin use. The reaction can be immediate and severe. Allergic symptoms include wheezing, hives, itching, swelling, spasms in the throat and breathing tubes, joint and muscle pain, difficulty breathing, fever and skin rashes. Nausea and vomiting are not symptoms of an allergic reaction.
Taking the antibiotic repeatedly or for prolonged periods may result in bacterial or fungal overgrowth which can lead to a second infection. When this occurs, the clarithromycin may need to be stopped and another antibiotic prescribed to treat the new infection.
Diarrhea often develops while taking clarithromycin. This is sometimes caused by an overgrowth of bacteria in the gut that are not killed by the antibiotic. In severe cases, this may be life threatening and would require treatment with other antibiotics. In mild cases, symptoms disappear shortly after the drug is discontinued.
Drug Interactions: It is important to tell your doctor and pharmacist of any prescription or over-the-counter medications you are taking. In some cases, the dose of one or both drugs may need to be altered or another drug may be prescribed. Interactions have been known to occur with the following drugs and drug classes.

  • anticoagulants (e.g. Coumadin®)
  • carbamazepine (e.g. Tegretol®)
  • cyclosporine (e.g. Neoral®)
  • digoxin (e.g. Lanoxin®)
  • disopyramide (e.g. Norpace®)
  • ergot-containing drugs (e.g. Ergomar®)
  • fluconazole (e.g. Diflucan®)
  • pimozide (e.g. Orap®)
  • zidovudine (e.g. Retrovir®)
  • theophylline (e.g. Theo-Dur®)
  • triazolam (e.g. Halcion®)
  • phenytoin (e.g. Dilantin®)
  • cholesterol reducing medications such as atorvastatin (e.g. Lipitor®), lovastatin (e.g. Mevacor®)

Use is not recommended in the following situations:
  • allergy to clarithromycin, erythromycin or any of the macrolide antibiotics
  • concurrent therapy with pimozide (e.g. Orap®)

Caution is recommended in the following situations:
  • kidney disease, severe
Use in pregnancy: Consult your doctor or pharmacist if you suspect that you may be pregnant. Use while breastfeeding: Clarithromycin passes into the breast-milk. Consult your doctor or pharmacist before you begin breastfeeding.

 

Patient Information

Use exactly as prescribed.
Ratio-Clarithromycin® tablets can be taken with or without food. Take Ratio-Clarithromycin® tablets at even intervals around the clock as prescribed (e.g. every 12 hours translates to twice a day) until finished. Failure to take the complete course can result in incomplete elimination of the bacteria which can lead to a relapse of the infection. The prescribed course generally lasts a few days longer than symptoms of the infection (e.g. fever). Treatment usually lasts 7 to 14 days. If you miss a dose, take it as soon as possible. If it is almost time for your next dose, do not take 2 doses at once (unless you have been instructed to do so). Contact your pharmacist if you are not sure what to do.
It is not unusual to experience the more common, unwanted effects with Ratio-Clarithromycin® tablets (e.g. nausea, diarrhea, etc.). Contact your doctor or pharmacist if they are severe, persist or become bothersome.
Ratio-Clarithromycin® tablets may produce an allergic reaction which can range in severity from a mild rash or itching to a life-threatening reaction. Contact your doctor or pharmacist if you experience rash, itching, fever, difficulty breathing, chest tightness or anything else that alarms you.

 

Directions for Use

The dose will depend on the type and severity of the infection. The usual adult dose of Ratio-Clarithromycin® for respiratory tract infections is 250 mg to 500 mg every 12 hours.

 

Lung Diseases Treated with this Drug

  • bronchitis
  • middle ear infections
  • pharyngitis
  • pneumonia
  • respiratory tract infections
  • sinus infections
  • sinusitis
  • sore throat
  • tonsilitis
  • upper respiratory tract infections

 

Need More Information?

For more information contact your physician, pharmacist, other health care professional or for general questions call your local lung association.